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Anti-Amyloid beta precursor protein Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Amyloid-beta precursor protein |
Synonyms: | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, amyloid beta precursor protein, preA4, β-Amyloid |
Immunogen: | Recombinant protein corresponding to Mouse Amyloid beta precursor protein (APP) |
Uniprot ID: | P12023 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane |
Predicted MW. / Observed MW. | 86 kDa / 100-140 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 800 | brain, cerebellum |
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | brain |
Background
Functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis.
Images
| Western blot analysis of APP(GB11307) at dilution of 1: 800 |
| Western blot analysis of APP(GB11307) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using APP(GB11307) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using APP(GB11307) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
