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Anti-Aquaporin 4 Mouse mAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Aquaporin-4 |
Synonyms: | AQP4, Aquaporin 4, HMIWC2, MIWC, WCH4, Aquaporin type 4, Mercurial-insensitive water channel, aquaporin 4 |
Immunogen: | Recombinant protein corresponding to Mouse Aquaporin 4 |
Uniprot ID: | P55088 |
Isotype: | IgG2b,κ |
Purity: | Affinity purification |
Subcellular location: | Membrane |
Images
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 2000 | brain, kidney, lung |
Background
Aquaporin-4, also known as AQP4, is a water channel protein, belonging to the aquaporin family of integral membrane proteins that conduct water through the cell membrane. In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. Aquaporin-4’s overall function is to provide fast water transportation as well as maintain homeostatic balance within the central nervous system. Other systems are also regulated by AQP4.
Images
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Immunohistochemistry of paraffin embedded mouse kidney using AQP4 (GB12529) at dilution of 1: 700 (350x lens) |
 | Immunohistochemistry of paraffin embedded rat kidney using AQP4 (GB12529) at dilution of 1: 700 (350x lens) |
 | Immunofluorescence of paraffin embedded mouse brain using AQP4 (GB12529) at dilution of 1: 1000 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse kidney using AQP4 (GB12529) at dilution of 1: 000 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse lung using AQP4 (GB12529) at dilution of 1: 1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse muscle using AQP4 (GB12529) at dilution of 1: 1000 (400x lens) |
| IHC analysis of AQP4(GB12529). Sample: Human glioblastoma multiforme,4% PFA (G1101) 12-24h. Antigen retrieval:citrate buffer (pH 6.0) (G1201)，98°C，20min. Primary antibody:1: 1000, 4°C overnight. Secondary antibody:HRP Goat Anti-Mouse lgG (GB23301), 1: 200, RT, 1h. |
| IHC analysis of AQP4(GB12529). Sample: Human stomach,4% PFA (G1101) 12-24h. Antigen retrieval:citrate buffer (pH 6.0) (G1201)，98°C，20min. Primary antibody:1: 1000, 4°C overnight. Secondary antibody:HRP Goat Anti-Mouse lgG (GB23301), 1: 200, RT, 1h. |
| IHC analysis of AQP4(GB12529). Sample: Human lung,4% PFA (G1101) 12-24h. Antigen retrieval:citrate buffer (pH 6.0) (G1201)，98°C，20min. Primary antibody:1: 1000, 4°C overnight. Secondary antibody:HRP Goat Anti-Mouse lgG (GB23301), 1: 200, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
