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Anti-Artemis Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Artemis rabbit polyclonal antibody |
Gene Name: | Protein artemis |
Synonyms: | MArt, DNA cross-link repair 1C protein, SNM1-like protein, Dclre1c, Art, Snm1l, Artemis protein, SCIDA, SNM1C, ASCID |
Immunogen: | Recombinant protein corresponding to Mouse Artemis |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 79 kDa |
Observed MW. | 79 kDa |
Uniprot ID: | Q8K4J0, Q5XIX3 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 300-1: 600 | kidney, skeletal muscle |
Background
Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins.
Images
 | Western blot analysis of Dclre1c (GB112410) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
