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| Reactivity: | H,M,R & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CIRP rabbit polyclonal |
Gene Name: | Cold-inducible RNA-binding protein |
Synonyms: | A18HNRNP, CIRBP, CIRP, Glycine-rich RNA-binding protein CIRP, testicular tissue protein Li 39 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CIRP |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 19 kDa |
Observed MW. | 19kDa |
Uniprot ID: |
Product Usage Information
WB | Human, Mouse, Rat | 1: 700-1: 1400 | heart, placenta, kidney |
IHC/IF | Mouse | 1: 400-1: 800 | testis |
Background
CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation. CIRBP can translocate from nucleus to cytoplasm under stresses such as UV irradation or heat shock. Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature.
Images
| Western blot analysis of CIRBP (GB113734) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse testis using CIRBP (GB113734) at dilution of 1: 400 |
| Immunofluorescent analysis of paraffin embedded mouse testis using CIRBP (GB113734) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
