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Anti-FBXO2 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | F-box only protein 2 |
Synonyms: | F box only protein 2, F box protein 2, FBG1, Fbs1, FBX2, NFB42 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FBXO2 |
Uniprot ID: | Q80UW2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 34 kDa / 40 kDa |
Product Usage Information
WB | Human | 1: 800-1: 1500 | brain |
ICC/IF | Human | 1: 100-1: 600 | HeLa |
Background
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
Images
| Western blot analysis of FBXO2 (GB115017) at dilution of 1: 800 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed HeLa cells using FBXO2 (GB115017) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
