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Anti-FKBP6 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
Synonyms: | 36 kDa FK506 binding protein, 36 kDa FKBP, FK506 binding protein 6, FK506 binding protein 6, 36kDa, FKBP 36, FKBP 6, FKBP36, FKBP6, Immunophilin FKBP36, PPIase, PPIase FKBP6, Rotamase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FKBP6 |
Uniprot ID: | Q91XW8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 3000 | lung cancer, liver cancer, kidney |
Background
Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.
Images
| Immunohistochemistry analysis of paraffin embedded mouse lung cancer using FKBP6 (GB114949) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat lung cancer using FKBP6 (GB114949) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human liver cancer using FKBP6 (GB114949) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using FKBP6 (GB114949) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using FKBP6 (GB114949) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using FKBP6 (GB114949) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
