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Anti-HDAC4 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Histone deacetylase 4 |
Synonyms: | HA6116, HD4, HDAC A, HDAC4, HDACA, histone deacetylase 4, KIAA0288 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HDAC4 |
Uniprot ID: | Q6NZM9 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 50-1: 150 | kidney, renal carcinoma, cervical carcinoma |
Background
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
Images
| Immunohistochemistry analysis of paraffin embedded human cervical carcinoma using HDAC4 (GB115576) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded human renal carcinoma using HDAC4 (GB115576) at dilution of 1: 50-1: 150 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using HDAC4 (GB115576) at dilution of 1: 50-1: 150 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using HDAC4 (GB115576) at dilution of 1: 50-1: 150 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
