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Anti-HLA-B Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | HLA class I histocompatibility antigen, B alpha chain |
Synonyms: | AS, HLA B, HLA B 7301, HLA B73, HLA class I (HLA-B), HLAB, HLA-B, HLAC, MHC class I antigen B*7, SPDA1 |
Immunogen: | Recombinant protein corresponding to Human HLA-B |
Uniprot ID: | P01889 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 40 kDa / 43 kDa |
Product Usage Information
WB | Human | 1: 1000-1: 2000 | Raji |
Background
Antigen-presenting major histocompatibility complex class I (MHCI) molecule.In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells.May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity.Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells.
Images
| WB analysis of HLA-B(GB115623). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
