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Anti-HtrA2 / Omi Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HtrA2 rabbit polyclonal antibody |
Gene Name: | Serine protease HTRA2, mitochondrial |
Synonyms: | High temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, HtrA like serine protease, HtrA serine peptidase 2, Serine protease htra2 mitochondrial precursor, PARK 13, Protease serine 25, Serine p |
Immunogen: | Recombinant protein corresponding to Mouse HtrA2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 49 kDa |
Observed MW. | 39 kDa |
Uniprot ID: | O43464 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500- 1: 1000 | 293T, HeLa, MCF7 |
Background
This (HtrA2)/Omi is a serine protease with homology to the E.coli HtrA protein (DegP) and is thought to be involved inapoptosis and stress induced degradation of misfolded proteins. While HtrA2 was orignally identified to bepresent in either the nucleus or endoplasmic reticulum, subsequent studies have shown that it localizes in mitochondria and is released during apoptosis. HtrA2 is produced as a 50 kDa zymogen that is cleaved to generate a 36 kDa mature protein that exposes an amino terminal motif (AVPS) resembling that of the IAP inhibitor Smac/Diablo. research studies have shown that loss of function mutations in the HtrA2 gene are associated with Parkinson’s disease.
Images
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Western blot analysis of htar2 (GB11982) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
