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Anti-IKB alpha Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | NF-kappa-B inhibitor alpha |
Synonyms: | I kappa B alpha, IkappaBalpha, IkB alpha, IKBA, Ikβ-α, MAD 3, MAD3, NF kappa B inhibitor alpha, NFKBI, NFKBIA |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse IKBα |
Uniprot ID: | |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 500-1: 3000 | lung cancer, liver cancer, stomach cancer |
IF | Human | 1: 500-1: 1000 | lung cancer, liver cancer, stomach cancer |
Background
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Images
 | Immunohistochemistry analysis of paraffin-embedded human lung cancer using IKBα (GB11212) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human colon cancer using IKBα (GB11212) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human stomach cancer using IKBα (GB11212) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
