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Anti-KBTBD8 Rabbit pAb (100 μl)
| Reactivity: | H & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Kelch repeat and BTB domain-containing protein 8 |
Synonyms: | KIAA1842, TA-KRP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse KBTBD8 |
Uniprot ID: | Q3UQV5 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cytoskeleton |
Predicted MW. / Observed MW. | 69 kDa / 69 kDa |
Product Usage Information
WB | Human | 1: 2000-1: 4000 | Jurkat |
IHC/IF | Human, Mouse, Rat | 1: 700-1: 2100 | kidney cancer, liver, colon, heart |
Background
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Images
| Western blot analysis of KBTBD8 (GB115205) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded human kidney cancer using KBTBD8 (GB115205) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded human liver using KBTBD8 (GB115205) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded mouse colon using KBTBD8 (GB115205) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded mouse heart using KBTBD8 (GB115205) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded rat colon using KBTBD8 (GB115205) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded rat heart using KBTBD8 (GB115205) at dilution of 1: 700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |