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Anti-KIF5B Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | KIF5B rabbit polyclonal |
Gene Name: | Kinesin-1 heavy chain |
Synonyms: | Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC, Kif5b, Khcs, Kns1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse KIF5B |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cytoskeleton |
Predicted MW. | 110 kDa |
Observed MW. | 130 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 2000-1: 4000 | heart, brain, uterus, skin |
IHC | Mouse, Rat | 1: 500-1: 1000 | substantia nigra, kidney, colon, skin, heart, hippocampus |
Background
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence . Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner . Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation .
Images
 | Western blot analysis of KIF5B (GB112572) at dilution of 1: 4000 Lane 1: Mouse heart tissue lysate Lane 2: Mouse brain tissue lysate Lane 3: Mouse uterus tissue lysate Lane 4: Mouse skin tissue lysate Lane 5: Rat heart tissue lysate Lane 6: Rat brain tissue lysate Lane 7: Rat uterus tissue lysate Lane 8: Rat skin tissue lysate |
| Immunohistochemistry analysis of paraffin-embedded mouse substantia nigra using KIF5B (GB112572) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using KIF5B (GB112572) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse colon using KIF5B (GB112572) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat colon using KIF5B (GB112572) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using KIF5B (GB112572) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat heart using KIF5B (GB112572) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat hippocampus using KIF5B (GB112572) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat heart using KIF5B (GB112572) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
