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Anti-Kidins220 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Kinase D-interacting substrate of 220 kDa |
Synonyms: | ARMS, KIAA1250, KIDINS220 |
Immunogen: | Recombinant protein corresponding to Human Kidins220 |
Uniprot ID: | Q9ULH0 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 187 kDa / 190 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | K562,HeLa,293 |
Background
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism.Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation.May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4.In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation.Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
Images
| WB analysis of Kidins220(GB115613). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
