Your shopping cart is empty!
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Male-specific lethal 1 homolog |
Synonyms: | hMSL1, Male specific lethal 1 homolog, Male specific lethal 1 like 1, MSL 1, MSL1, MSL1 like 1, MSL1L1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MSL1 |
Uniprot ID: | Q6PDM1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 67 kDa / 68 kDa |
Product Usage Information
WB | Human, Mouse | 1: 300-1: 600 | brain |
Background
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure . Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub) . This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 . In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation . Isoform 2, isoform 3, isoform 4 and isoform 5 can medite histone H4 acetylation at 'Lys-16' (H4K16ac) .
Images
| Western blot analysis of MSL1 (GB114644) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
