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| Reactivity: | M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Chondroitin sulfate proteoglycan 4 |
Synonyms: | Chondroitin sulfate proteoglycan NG2, Proteoglycan AN2, Cspg4, An2, Kiaa4232, Ng2, MSK16, MELCSPG |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NG2 |
Uniprot ID: | Q8VHY0 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Mouse | 1: 100-1: 200 | kidney |
Background
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins.
Images
| IHC analysis of ng2 (GB115534). |
| IHC analysis of ng2 (GB115534). Sample: Mouse kidney (Paraffin), 4% PFA (G1101) 12-24h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
