Your shopping cart is empty!
Anti-RMND5A Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RMND5A rabbit polyclonal |
Gene Name: | E3 ubiquitin-protein ligase RMND5A |
Synonyms: | Protein RMD5 homolog A, Rmnd5a, CTHL, p44CTLH, RMD5 |
Immunogen: | Recombinant protein corresponding to Mouse RMND5A |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1500-1: 3000 | striatum, kidney |
IF | Mouse, Rat | 1: 600-1: 1200 | substantia nigra |
Background
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse striatum using RMND5A (GB112796) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded rat striatum using RMND5A (GB112796) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using RMND5A (GB112796) at dilution of 1: 3000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse substantia nigra using RMND5A (GB112796) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
