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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Transforming protein RhoA |
Synonyms: | ARH12, ARHA, h12, Rho cDNA clone 12, RHO12, RHOA, RHOH12 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human RhoA |
Uniprot ID: | P61586 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm, Cytoskeleton |
Predicted MW. / Observed MW. | 23 kDa / 23 kDa |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 2000 | liver cancer, endometrial cancer, kindey, heart |
Background
RhoA is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of RhoA is associated with tumor cell proliferation and metastasis. RhoA signalling is critical to many cellular processes including migration, mechanotransduction, and is often disrupted in carcinogenesis.
Images
| Immunohistochemistry analysis of paraffin embedded human liver cancer using RhoA (GB115177) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human endometrial cancer using RhoA (GB115177) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat kindey using RhoA (GB115177) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse kindey using RhoA (GB115177) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat heart using RhoA (GB115177) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse heart using RhoA (GB115177) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
