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Anti-TFII I Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TFII I rabbit polyclonal |
Gene Name: | General transcription factor II-I |
Synonyms: | BAP135, BTK associated protein 135, BTKAP1, DIWS, GTF2I, GTFII I, IB291, SPIN, SRF Phox1 interacting protein, TFII I, WBS, WBSCR6 |
Immunogen: | Recombinant protein corresponding to Mouse TFII I |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 4800-1: 9600 | esophageal cancer, breast cancer, lung cancer, colon, esophagus, placenta, brain, testis, lung, spinal cord |
Background
The GTF2I gene encodes a transcription factor. It negatively regulates agonist-induced calcium entry into cells by interfering with expression of the cation channel TRPC3 at the plasma membrane . As a transcription factor and/or as a regulator of intracellular calcium levels, GTF2I may play a role in the molecular basis of anxiety . It interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation .
Images
| Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded human breast cancer using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded human lung cancer using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded human colon using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded human esophagus using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded human placenta using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded human brain using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded rat brain using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded mouse lung using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded rat spinal cord using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded mouse testis using TFII I (GB113138) at dilution of 1: 9600 |
| Immunohistochemistry analysis of paraffin-embedded rat testis using TFII I (GB113138) at dilution of 1: 9600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
